Recently our research letter was accepted for publication in Brain. In this paper we show for the first time that CAG repeat length variations in genes other than the HTT gene may also affect phenotype in patients with Huntington disease. Interestingly, only two weeks after our paper was accepted for publication, another intriguing paper was published in Nature by David Rubinsztein’s group which could provide a mechanistic basis for interactions among polyglutamine-disease associated genes through polyglutamine-length dependent competitive interactions among the encoded proteins and regulators of autophagy. Fascinating!
Curious Brain 