The prevalence of carriers of intermediate and pathological range polyglutamine disease-associated alleles is much higher in the general population than previously thought. So a substantially higher number of individuals may be at risk of developing a polyglutamine disease (including Huntington disease and spinocerebellar ataxias) later in life or bearing children with a de novo mutation (given the well-known germ-line instability of longer alleles) than previously assumed. See our study on this topic recently published in JAMA Neurology (https://lnkd.in/dU8Aehi) and the accompanying editorial (https://lnkd.in/dXkhFWk).
Curious Brain 