Determinants of age-at-onset and disease progression largely overlap in Huntington disease

It was a bit of a mathematical tour de force, but very much worth the effort: The determinants of age-at-onset and disease progression largely overlap in Huntington disease. This indicates that any treatment which is able to delay age-at-onset is also very likely to slow the rate of disease progression in people who already have clinically manifest disease, and vice versa.